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Advances in Large-Scale Biopharmaceutical Manufacturing
and Scale-Up Production*, 2nd Edition

    Design of Large-Scale Cell Culture Process

    Abstract:
    Design of large-scale cell culture process is a complex task. It has received increasing interest due to the increased market demand for cell culture derived biotherapeutics. This article will provide an overview of the typical unit operations associated with large-scale cell culture process, both upstream and downstream, as well as supporting functions. It emphasizes cell culture process scale-up methodology, as well as key equipment and facility design considerations as they occur in different engineering design phases. The article also discusses current trends and innovation in the cell culture facility, equipment, engineering design approach and practice.


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